There are 10 to 1 times as many bacteria as cells in the human body, per the National Institutes of Health. It is important for human health to have a wide variety of microbes, although not all of them are beneficial. Bacterial infections may cause a wide range of health problems, including anything from autoimmune disease to inflammation to infections to the flu. Other harmful bacteria may find their way into the body and cause bacterial illnesses, including Lyme disease, Rocky Mountain Spotted Fever (RMSF), environmental toxicity, STDs, and leaky gut, amongst other possibilities. It’s possible that the LL-37 peptide holds the key to curing all of these ailments.
Peptide LL-37: what is it, and how does it work?
In place of antibiotics, LL-37 is an antimicrobial peptide (AMP) from the cathelicidin family. In addition to killing bugs, an AMP controls bacterial invasions, infections, and inflammation. It can do all of this and more. There are numerous issues in which the peptide is made and circulates throughout the body, including bone marrow, epithelial, and intestinal cell types. In contrast, if the body isn’t producing enough, it leaves itself open to infection by harmful bacteria, leading to the buildup of pathogens and the onset of chronic illnesses and inflammation. Amino acids included in peptides allow proteins to be released, allowing the body to concentrate on fine-tuning certain physiological processes. LL-37 helps patients develop antibodies and combat infectious infections by containing between 12 and 80 amino acids.
The Advantages of LL-37 Peptide
After a wound, infection, or inflammation occurs, Peptide LL-37 is the first line of defense. Tick-borne diseases such as Lyme, RMSF, Anaplasmosis, Babesia, and Colorado Tick Fever may be effectively treated with this peptide. Peptide treatment for diabetes, E. Coli, Candida Albicans, and certain forms of cancer have also been shown in other studies. However, apart from its anti-biofilm characteristics, this peptide is also well-known for its function in controlling inflammatory molecules and for its ability to repair injured tissues. People with autoimmune diseases, IBD, arthritis, or Lupus will particularly benefit from this.
Antimicrobial peptides
These antimicrobial peptides play a critical role in the body’s natural defenses against illness. It is estimated that approximately 1480 different AMPs are active against a wide range of microorganisms. Many of these AMPs are cationic and amphipathic, ranging in size from 12 to 100 amino acids, structurally varied, and capable of binding to and disrupting microbe membranes. AMPs are chemotactic for many leukocytes, attracting them to the site of infection or inflammation, and may decrease the production of cell walls, nucleic acid, and protein. The ability to bind and neutralize lipopolysaccharides (LPS) to promote angiogenesis and wound healing, as well as exhibit anti-tumor action, have all been shown by these compounds. However, even after millions of years of co-evolution, bacteria haven’t acquired widespread resistance to AMPs, giving them an edge over other antimicrobial drugs.
LL-37 and wounds
An equilibrium between expression, degradation, and serum protein binding controls the number of free LL-37 in the wound. To further complicate matters, the pathogen may stimulate the production of LL-37 via the LPS present in Gram-negative bacteria’s outer membrane. These cytokines are released as a result of an interaction with the toll-like receptor 4 (TLR4) and subsequent release. It’s been shown that LPS may be neutralized by attaching to LL-37, which prevents LPS from interacting with the lipopolysaccharide-binding protein (LBP) and the co-receptor CD14. You can buy LL-37 peptide online in case you have a license and want to further research its potential.
